Abstract NLRP3 induces caspase-1-dependent pyroptotic cell death to drive inflammation.Aberrant activity of NLRP3 occurs in many human diseases.NLRP3 activation induces ASC polymerization into a single, Broth micron-scale perinuclear punctum.Higher resolution imaging of this signaling platform is needed to understand how it induces pyroptosis.Here,

Indoor radon is the second cause of lung cancer.Mitigation strategies are based on (i) building protection with radon barrier materials, (ii) increasing home ventilation or (iii) room pressurization.A scale model room created with a porous ignimbrite rich Fountain Pen in radon precursors was used as an analogue to test the indoor radon reduction ab

The environmental situation that has developed in Russia and around the world, the global nature of environmental problems and their peculiar manifestation in each region of the planet urgently require an early change of the thinking of humanity, individual peoples and Suspension Lift Kit each individual person.One of the reasons for this situation

Abstract The development of multitarget small molecules (MSMs) has emerged as a powerful strategy for the treatment of multifactorial diseases such as cancer.Glioblastoma is the most prevalent and malignant primary brain tumor in adults, which is characterized by poor prognosis and a high heterogeneity.Current standards of treatment present limited